A NEW INHIBITOR OF PROTEIN KINASE C, RK-1409 (7-OXOSTAUROSPORINE)
II. FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE
1992 Volume 45 Issue 2 Pages 195-198
Details
1992 Volume 45 Issue 2 Pages 195-198
RK-1409, a new inhibitor of protein kinase C, was isolated from the culture broth of Streptomyces platensis subsp. malvinus RK-1409. The structure was elucidated as 7-oxostaurosporine on the basis of spectroscopic analyses and oxidation of staurosporine.
