TERPESTACIN, A NEW SYNCYTIUM FORMATION INHIBITOR FROM Arthrinium sp.

MASAHISA OKA; SEIJI IIMURA; OSAMU TENMYO; YOSUKE SAWADA; MASARU SUGAWARA; NORIYUKI OHKUSA; HARUAKI YAMAMOTO; KIMIO KAWANO; SHIU-LOK HU; YASUO FUKAGAWA; TOSHIKAZU OKI

doi:10.7164/antibiotics.46.367

TERPESTACIN, A NEW SYNCYTIUM FORMATION INHIBITOR FROM Arthrinium sp.

MASAHISA OKA, SEIJI IIMURA, OSAMU TENMYO, YOSUKE SAWADA, MASARU SUGAWARA, NORIYUKI OHKUSA, HARUAKI YAMAMOTO, KIMIO KAWANO, SHIU-LOK HU, YASUO FUKAGAWA, TOSHIKAZU OKI

Author information

MASAHISA OKA
Bristol-Myers Squibb Research Institute
SEIJI IIMURA
Bristol-Myers Squibb Research Institute
OSAMU TENMYO
Bristol-Myers Squibb Research Institute
YOSUKE SAWADA
Bristol-Myers Squibb Research Institute
MASARU SUGAWARA
Bristol-Myers Squibb Research Institute
NORIYUKI OHKUSA
Bristol-Myers Squibb Research Institute
HARUAKI YAMAMOTO
Bristol-Myers Squibb Research Institute
KIMIO KAWANO
Bristol-Myers Squibb Research Institute
SHIU-LOK HU
Bristol-Myers Squibb Pharmaceutical Research Institute
YASUO FUKAGAWA
Bristol-Myers Squibb Research Institute
TOSHIKAZU OKI
Bristol-Myers Squibb Research Institute

JOURNAL FREE ACCESS

1993 Volume 46 Issue 3 Pages 367-373

DOI https://doi.org/10.7164/antibiotics.46.367

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Abstract

Terpestacin, a new antibiotic which inhibits syncytium formation, was isolated from Arthrinium sp. FA1744 (ATCC 74132). The structure of terpestacin was elucidated as a bicyclic sesterterpene on the basis of spectroscopic data and chemical derivatization.

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