Studies on New Antitumor Antibiotics, Leptofuranins A, B, C and D I. Taxonomy, Fermentation, Isolation and Biological Activities

YOICHI HAYAKAWA; KIN-YA SOHDA; KEIKO FURIHATA; TOMOHISA KUZUYAMA; KAZUO SHIN-YA; HARUO SETO

doi:10.7164/antibiotics.49.974

Studies on New Antitumor Antibiotics, Leptofuranins A, B, C and D

I. Taxonomy, Fermentation, Isolation and Biological Activities

YOICHI HAYAKAWA, KIN-YA SOHDA, KEIKO FURIHATA, TOMOHISA KUZUYAMA, KAZUO SHIN-YA, HARUO SETO

Author information

JOURNAL FREE ACCESS

1996 Volume 49 Issue 10 Pages 974-979

DOI https://doi.org/10.7164/antibiotics.49.974

Details

Abstract

The retinoblastoma protein (pRB) is inactivated in a wide variety of human cancers. In the course of our screening for antitumor antibiotics by using pRB-inactivated cells, an actinomycete identified as Streptomyces tanashiensis was found to produce four new active substances, leptofuranins A, B, C and D. The leptofuranins arrested the growth of normal cells and induced apoptotic cell death against tumor cells and cells transformed with the adenovirus E1A gene.

Corresponding author

Register with J-STAGE for free!