CJ-12, 954 and Its Congeners, New Anti-Helicobacter pylori Compounds Produced by Phanerochaete velutina: Fermentation, Isolation, Structural Elucidation and Biological Activities

KOEN A. DEKKER; TAISUKE INAGAKI; THOMAS D. GOOTZ; KEIJI KANEDA; ETSUKO NOMURA; TATSUO SAKAKIBARA; SHINICHI SAKEMI; YUTAKA SUGIE; YUJI YAMAUCHI; NOBUJI YOSHIKAWA; NAKAO KOJIMA

doi:10.7164/antibiotics.50.833

CJ-12, 954 and Its Congeners, New Anti-Helicobacter pylori Compounds Produced by Phanerochaete velutina:

Fermentation, Isolation, Structural Elucidation and Biological Activities

KOEN A. DEKKER, TAISUKE INAGAKI, THOMAS D. GOOTZ, KEIJI KANEDA, ETSUKO NOMURA, TATSUO SAKAKIBARA, SHINICHI SAKEMI, YUTAKA SUGIE, YUJI YAMAUCHI, NOBUJI YOSHIKAWA, NAKAO KOJIMA

Author information

KOEN A. DEKKER
Central Research Division, Pfizer Pharmaceuticals Inc.
TAISUKE INAGAKI
Central Research Division, Pfizer Pharmaceuticals Inc.
THOMAS D. GOOTZ
Central Research Division, Pfizer Inc.
KEIJI KANEDA
Central Research Division, Pfizer Pharmaceuticals Inc.
ETSUKO NOMURA
Central Research Division, Pfizer Pharmaceuticals Inc.
TATSUO SAKAKIBARA
Central Research Division, Pfizer Pharmaceuticals Inc.
SHINICHI SAKEMI
Central Research Division, Pfizer Pharmaceuticals Inc.
YUTAKA SUGIE
Central Research Division, Pfizer Pharmaceuticals Inc.
YUJI YAMAUCHI
Central Research Division, Pfizer Pharmaceuticals Inc.
NOBUJI YOSHIKAWA
Central Research Division, Pfizer Pharmaceuticals Inc.
NAKAO KOJIMA
Central Research Division, Pfizer Pharmaceuticals Inc.

JOURNAL FREE ACCESS

1997 Volume 50 Issue 10 Pages 833-839

DOI https://doi.org/10.7164/antibiotics.50.833

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Abstract

Seven new phthalide compounds with anti-Helicobacter pylori activities were isolated from the basidiomycete Phanerochaete velutina CL6387, The two most potent phthalide compounds, CJ-12, 954 and CJ-13, 014, have MICs of 5ng/ml. The structure-activity relationship shows that the presence of a spiroketal part in addition to the phthalide part, greatly enhances the activity. The phthalide compounds appear to be specific for H. pylori, since they did not show antibacterial activities when tested against a panel of other microorganisms.

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