TITRATION OF BOTULINUM TOXINS FOR LETHAL TOXICITY BY INTRAVENOUS INJECTION INTO MICE

Hisashi KONDO; Tomoko SHIMIZU; Masaru KUBONOYA; Nanae IZUMI; Motohide TAKAHASHI; Genji SAKAGUCHI

doi:10.7883/yoken1952.37.131

Japanese Journal of Medical Science and Biology

Online ISSN : 1884-2828
Print ISSN : 0021-5112
ISSN-L : 0021-5112

TITRATION OF BOTULINUM TOXINS FOR LETHAL TOXICITY BY INTRAVENOUS INJECTION INTO MICE

Hisashi KONDO, Tomoko SHIMIZU, Masaru KUBONOYA, Nanae IZUMI, Motohide TAKAHASHI, Genji SAKAGUCHI

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1984 Volume 37 Issue 3 Pages 131-135

DOI https://doi.org/10.7883/yoken1952.37.131

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Abstract

Clostridium botulinum type A - F toxins can be titrated by the time-to-death method by iv injection into mice. The time to death is not dependent upon the molecular size, but upon the immunological type of the toxin. It is necessary to assure complete activation of the activable toxin produced by nonproteolytic as well as a certain proteolytic strains before subjecting to titration by the iv injection method.

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